In Clinical Practice: Overcoming Patient Barriers to PrEP

Volume 1, Issue 2

In this issue:

PrEP — pre-exposure prophylaxis to prevent HIV transmission — is safe, it’s effective, and it’s significantly underused in the U.S.  One key barrier to increased PrEP use is a lack of awareness and acceptance among the patient populations most at-risk for new HIV infection.

In this podcast, Dr. Douglas Krakower from Harvard Medical School takes us into the exam room to translate the new information in his Newsletter Issue into clinical practice.

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Clinical Aspects of Improving ART Adherence

Volume 4, Issue 10

In this Issue, Dr. Joyce Jones from the Johns Hopkins University School of Medicine and Dr. Barbara Taylor from the University of Texas Health Science Center at San Antonio analyze recent publications describing evidence-based ART adherence interventions and how they can be tailored to specific situations to increase effectiveness.

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Patients’ DMT Decision-Making

Volume 2, Issue 4

In this issue, Dr. Ellen Mowry, Associate Professor of Neurology and Epidemiology at the Johns Hopkins University School of Medicine, brings recent findings about patient decision-making and addressing common comorbidities into the MS clinic.

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Clinical Perspective: New AEs from Newer ART

Volume 4, Issue 8

While newer antiviral agents like darunavir and the integrase strand transfer inhibitor (INSTI) dolutegravir have shown great efficacy, recent postmarketing surveillance has identified important adverse effects not found in the clinical trial populations.

In this issue, Dr. Cody Chastain from the Division of Infectious Diseases at Vanderbilt University Medical Center discusses how these new findings can impact the clinical use of these new agents.

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Clinical Insight: CFTR Modulators

Volume 8, Issue 6.

In this issue, Dr. Gregory Sawicki — Associate Professor of Pediatrics at Harvard Medical School and Director of the Cystic Fibrosis Center at Boston Children’s Hospital — discusses how the recent findings about the real-world use of CFTR modulators can impact clinical practice.

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Clinical Markers for MS Diagnosis and Prognosis

Volume 2, Issue 2

The central vein sign. Optical coherence tomography. Serum neurofilament light chain. New research has identified these markers as valuable in discriminating MS from mimicking conditions, and in predicting future disability.

In this Issue, Dr. Michael Kornberg and Dr. Elias Sotirchos from the Johns Hopkins University School of Medicine discuss how these advances can impact clinical decision-making to provide better patient care.

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Clinical Challenges of Engaging PWID and MSM in HIV Care

Volume 4, Issue 6.

Linking high-risk populations like PWIDs (people who inject drugs) and MSM (men who have sex with men) to effective HIV care requires overcoming complex barriers unique to these groups.

In this issue, two of the directors from Boston’s Health Care for the Homeless Program, Dr. Jennifer Brody, Director of HIV Services and ANP Marguerite Beiser, Director of HCV Services, discuss the clinical aspects of addressing these challenges.

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Clinical Approaches to MDR Lung Infections

Volume 8, Issue 4.

Multidrug resistant lung infections present an increasingly common and increasingly dangerous threat to all individuals with cystic fibrosis.  Common CF pathogens — Pseudomonas aeruginosa, Burkholderia cepacia complex, Achromobacter xylosoxidans, Stenotrophomonas maltophilia — are all showing increasing resistance to clinicians’ usual antibiotic armamentarium.

In this issue, Dr. Claire Elson, from the University of Missouri Kansas City School of Pharmacy, and Dr. Christopher Oermann, from the UMKC School of Medicine, describe strategies for the clinical management of these resistant infections.

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In the Clinic: ART and Metabolic Effects

Volume 4, Issue 4.

The incidence of the metabolic complications common in people with HIV infection — bone disease, weight gain, cardiovascular disease, and liver disease — is increasing as improved antiretroviral therapies create longer lifespans.

In this issue, Dr. Suman Srinivasa and nurse practitioner Kathleen Fitch from Harvard Medical School discuss how to identify and manage these metabolic complications to help improve outcomes and quality of life in patients living with HIV.

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Lung Transplant and CRC Screening

Volume 8, Issue 2.

Screening to avoid the morbidity and mortality of colorectal cancer (CRC) in patients with CF, with the incidence of CRC rising, has become an increasingly important challenge, particularly among lung transplant patients.  But how and when should patients be screened? With colonoscopy or non-invasive FIT? Before or after transplant?  Are there patients who should not be screened, and why?

In this issue, Dr. Denis Hadjiliadis from the Perelman School of Medicine at the University of Pennsylvania discusses the clinical aspects of screening patients with CF to prevent CRC.

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