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Successful management of multiple sclerosis has gone beyond slowing disease progression and preventing relapses. Improving patients’ health-related quality of life by recognizing and addressing the pervasive chronic symptoms of the disease — spasticity, fatigue, depression, cognitive dysfunction — has become increasingly important. In this eMultipleSclerosis Review Podcast, Dr. Bardia Nourbakhsh from the Johns Hopkins School of Medicine provides clinical insight into reducing the disease burden of these common symptoms.