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Antibiotics, Dosing, and CFTR

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Airway infections are a hallmark of cystic fibrosis, making antibiotic therapies a mainstay of CF treatment. While the fight against ABX resistance is ongoing, newer data are showing that commonly used dosing regimens may have to be altered to account for the particular pharmacodynamics in people with CF. How should ABX dosing be altered, and what additional effect might CFTR modulation have on dosing decisions?

That’s the topic Dr. Andrea Hahn, Assistant Professor of Pediatrics and an Infectious Disease Specialist at Children’s National Medical Center and George Washington University School of Medicine and Health Sciences, addresses in this eCysticFibrosis Review podcast. 

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In the Clinic: Triple Combination CFTR Modulation

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Elexacaftor/tezacaftor/ivacaftor — the newly approved triple combination CFTR modulator therapy.  What are the benefits?  For which patients?  What are the potential adverse effects?  Who’s most likely to receive them?  

In this issue, Dr. Scott Sagel from the Breathing Institute at the Children’s Hospital Colorado, part of the University of Colorado’s Anschutz Medical Campus, takes us to the clinic to discuss some answers. 

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In The Clinic: CFTR Modification & Nutritional Deficiencies

Volume 8, Issue 9.

In this issue:

The effects of CFTR modifiers on improving lung function in people with cystic fibrosis are well known. But what about their effects on the GI tract that directly affect nutrition?

In this issue, Dr. Michael Wilschanski — Director of Hadassah Hospital’s Pediatric Gastroenterology Unit at Hebrew University in Jerusalem — explains how new findings about CFTR modification can impact clinical practice.

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Clinical Insight: CFTR Modulators

Volume 8, Issue 6.

In this issue, Dr. Gregory Sawicki — Associate Professor of Pediatrics at Harvard Medical School and Director of the Cystic Fibrosis Center at Boston Children’s Hospital — discusses how the recent findings about the real-world use of CFTR modulators can impact clinical practice.

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Clinical Approaches to MDR Lung Infections

Volume 8, Issue 4.

Multidrug resistant lung infections present an increasingly common and increasingly dangerous threat to all individuals with cystic fibrosis.  Common CF pathogens — Pseudomonas aeruginosa, Burkholderia cepacia complex, Achromobacter xylosoxidans, Stenotrophomonas maltophilia — are all showing increasing resistance to clinicians’ usual antibiotic armamentarium.

In this issue, Dr. Claire Elson, from the University of Missouri Kansas City School of Pharmacy, and Dr. Christopher Oermann, from the UMKC School of Medicine, describe strategies for the clinical management of these resistant infections.

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Lung Transplant and CRC Screening

Volume 8, Issue 2.

Screening to avoid the morbidity and mortality of colorectal cancer (CRC) in patients with CF, with the incidence of CRC rising, has become an increasingly important challenge, particularly among lung transplant patients.  But how and when should patients be screened? With colonoscopy or non-invasive FIT? Before or after transplant?  Are there patients who should not be screened, and why?

In this issue, Dr. Denis Hadjiliadis from the Perelman School of Medicine at the University of Pennsylvania discusses the clinical aspects of screening patients with CF to prevent CRC.

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CFTR Modulators: Clinical Insights

Volume 7, Issue 12.

In this podcast Dr. John P. Clancy reviews CFTR modulators, and discusses insights presented at the 2017 NACFC.

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Screening and Diagnosis of CFRD

Volume 7, Issue 10.

In this podcast Andrea Granados, MD describes the clinical impact of the early diagnosis of glucose abnormalities in people with CF, summarizes the limitations of alternative modalities for screening and diagnosing CFRD, and and identifies the current recommendations for the management of CFRD.

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New Directions in CFTR Modification

Volume 7, Issue 8.

In this podcast Dr. George Solomon discusses new directions in CFTR modification in the context of case studies.

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Future Landscape of CFTR Modulators

Volume 6, Issue 12.

Claire Wainwright, FRACP, MD and Tonia Douglas, MD cover the important topic of the Future Landscape of CFTR Modulators in the format of case-study scenarios for the clinical practice.

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